मार्कण्डेय-पुराणम् mārkaṇḍeya-purāṇam - chapter-12, verse-21

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दुः खस्य हेतुभूतानि पापकर्मकृतां नृणाम् ।
चक्रेष्वारोपिताः केचिद् भ्राम्यन्ते तत्र मानवाः ॥२१॥

21. duḥ khasya hetubhūtāni pāpakarmakṛtāṃ nṛṇām .
cakreṣvāropitāḥ kecid bhrāmyante tatra mānavāḥ.

21. duḥkhasya hetubhūtāni pāpakarmakṛtām nṛṇām
cakreṣu āropitāḥ kecit bhrāmyante tatra mānavāḥ

21. These become the cause of suffering for people (nṛ) who commit evil deeds (pāpakarmakṛts). There, some human beings (mānavas) are fastened to the wheels and are whirled around.

Words meanings summery:

(Scroll down for elaborated words morphology)

दुःखस्य (duḥkhasya) - of suffering (of suffering, of pain)

हेतुभूतानि (hetubhūtāni) - become the cause (having become the cause, being the cause)

पापकर्मकृताम् (pāpakarmakṛtām) - of people (nṛ) who commit evil deeds (pāpakarmakṛts) (of those who perform evil deeds, of sinners)

नृणाम् (nṛṇām) - of people (nṛ) (of men, of human beings, of people)

चक्रेषु (cakreṣu) - on the wheels (on the wheels, in the discs)

आरोपिताः (āropitāḥ) - fastened, fixed (placed, mounted, caused to ascend, fixed)

केचित् (kecit) - some (human beings) (some, certain ones, a few)

भ्राम्यन्ते (bhrāmyante) - they are whirled around (they are whirled, they are spun, they wander)

तत्र (tatra) - there (there, in that place)

मानवाः (mānavāḥ) - human beings (mānavas) (human beings, men)

Words meanings and morphology

दुःखस्य (duḥkhasya) - of suffering (of suffering, of pain)

(noun)

Genitive, neuter, singular of duḥkha

duḥkha - suffering, pain, misery, sorrow

हेतुभूतानि (hetubhūtāni) - become the cause (having become the cause, being the cause)

(adjective)

Nominative, neuter, plural of hetubhūta

hetubhūta - having become the cause, being the cause, caused

Past Passive Participle

Compound of `hetu` (cause) and `bhūta` (become).

Compound type : tatpuruṣa (hetu+bhūta)

hetu – cause, reason, motive
noun (masculine)
Root: hi (class 3)
bhūta – become, existed, past, being, element
adjective (masculine)
Past Passive Participle
From root `bhū` (to be, to become) + `ta` suffix.
Root: bhū (class 1)

Note: Also could be accusative plural neuter. Refers to the instruments from the previous verse.

पापकर्मकृताम् (pāpakarmakṛtām) - of people (nṛ) who commit evil deeds (pāpakarmakṛts) (of those who perform evil deeds, of sinners)

(noun)

Genitive, masculine, plural of pāpakarmakṛt

pāpakarmakṛt - one who performs evil deeds, sinner

Agent noun

Compound of `pāpa` (sin), `karman` (deed), and `kṛt` (doer). `kṛt` is from root `kṛ` (to do).

Compound type : upapada-tatpuruṣa (pāpa+karman+kṛt)

pāpa – evil, sin, wicked
noun (neuter)
karman – action, deed, work, (karma)
noun (neuter)
From root `kṛ` + `man` suffix
Root: kṛ (class 8)
kṛt – doer, maker, performing
noun (masculine)
Agent Noun
From root `kṛ` (to do) + `kvip` suffix.
Root: kṛ (class 8)

Note: Refers to men who perform `pāpakarma`.

नृणाम् (nṛṇām) - of people (nṛ) (of men, of human beings, of people)

(noun)

Genitive, masculine, plural of nṛ

nṛ - man, human being, person

Note: Refers to human beings.

चक्रेषु (cakreṣu) - on the wheels (on the wheels, in the discs)

(noun)

Locative, neuter, plural of cakra

cakra - wheel, disc, circle, discus

Root: kṛ

Note: The `ś` sound in the ending causes `ṣ`.